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. 2022 Jan 19;12:827256. doi: 10.3389/fimmu.2021.827256

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Copyright © 2022 Chang, Krenger, Krueger, Zha, Han, Yermanos, Roongta, Mohsen, Oxenius, Vogel and Bachmann

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Fel d 1-specific IgG BCR repertoires from Qβ_RNA-Fel d 1 and Qβ_empty-Fel d 1 immunized mice. (A, B) Diversity of IgG1, 2b, 2c repertoires in terms of CDR3 sequences (A) and VDJ combinations (B) at d10 and d17 after Qβ_RNA-Fel d 1 and Qβ_empty-Fel d 1 immunization. Diversity of each repertoire was determined as the clonotype counts normalized by read counts. (C) Frequency of IGHV gene usage by different repertoires. (D) Mutation frequency on germline IGHV sequences in Fel d 1-specific BCR repertoires; (E) Average mutations of IgG1 and IgG2b+2c repertoires at different time points after Qβ_RNA-Fel d 1 and Qβ_empty-Fel d 1 immunization. p value from unpaired t-test was indicated as ≤0.05 (*), ≤0.001 (***). The figure is representative of two independent experiments.