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. 2022 Jan 19;9:796451. doi: 10.3389/fcell.2021.796451

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Copyright © 2022 Ou, Zhou, Li, Ye, Liu, Fang, Cai, Cai, He and Xu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Identification of p53-regulated tumor suppressor lncRNAs in gastric cancer (A) Heat map is shown for the differentially expressed lncRNAs identified by RNA sequencing between three gastric cancer tissues and paired normal tissues (B,C) Isogenic TP53-WT AGS cells were untreated or treated with Nutlin-3 for 12 h, RT-qPCR and immunoblotting was performed for p53 and the loading control GAPDH (D) Heat map is shown for the differentially expressed lncRNAs identified by RNA sequencing in duplicate from AGS cells untreated or treated with nutlin-3 for 12 h. Upregulated genes are shown in red and downregulated genes in green (E,F) Venn diagram showing the overlap between the transcriptomes downregulated in gastric cancer tissues and the transcriptomes upregulated after nutlin-3 treatment of AGS cells.