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. 2022 Jan 19;9:796451. doi: 10.3389/fcell.2021.796451

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Copyright © 2022 Ou, Zhou, Li, Ye, Liu, Fang, Cai, Cai, He and Xu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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LINC00893 is significantly low-expressed in gastric cancer and regulated by p53 (A) Analysis of LINC00893 expression in unpaired GC (T = 408) and normal tissues (N = 211) in the GEPIA (p < 0.05) (B) Relative LINC00893 expression in 50 paired fresh frozen normal gastric tissues and gastric cancer tissues (C) Maximum CSF scores of LINC00893 as well as other coding and noncoding RNAs determined by analysis with PhyloCSF (D) Kaplan-Meier survival curve indicated the lower expression of LINC00893 associated with poorer survival rates (E,F) p53 and p21 expression in AGS treated with gradient nutlin-3 or 5-FU (G,H) p53 and p21 expression in AGS after transfection of TP53 siRNA or overexpression plasmid (I,J) LINC00893 expression in AGS treated with gradient nutlin-3 or 5-FU (K,L) LINC00893 expression in AGS after transfection of TP53 siRNA or overexpression plasmid. *p < 0.05, ****p < 0.0001, all RT-qPCR results were normalized to GAPDH.