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Platelet granule secretion stimulated with thrombin (concentrations: 0, 0.05, 0.1, 0.2, 0.5, and 1.0 U/ml) for all three index patients using flow cytometry. Severely impaired δ-granule secretion indicated by reduced platelet CD63 expression in IP1 (A), IP2 (B), and IP3 (C) compared to the healthy controls/day control. Data are expressed as logarithmic arbitrary units (logAU) of anti-CD63-stained unstimulated and thrombin-stimulated platelets.
