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. 2022 Jan 19;9:789438. doi: 10.3389/fcell.2021.789438

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Copyright © 2022 Buscaglia, Northington, Aiken, Hoff and Bates.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Tuba1a is required for formation of midline commissural structures. (A) Luxol fast blue-stained coronal brain sections from postnatal day 0 (P0; top) and Adult (middle-bottom) wild-type and Tuba1a ^ND/+ mice. Images portray abnormal midline commissural formation in Tuba1a ^ND/+ mouse brains, with labels highlighting the corpus callosum (CC), anterior commissures (AC), and hippocampal commissure (HC). Scale bars are 500 μm. Arrows indicate Probst bundles. Asterisk in A. shows where measurements for B. were obtained. (B) Scatter plot representing corpus callosum width at P0, 3 months, and 10 months-old. (C) Scatter plot displaying anterior commissure area in P0, 3 months, and 10 months-old wild-type and Tuba1a ^ND/+ brains. Wild-type and Tuba1a ^ND/+ measurements compared by two-way ANOVA. *p < 0.05; **p < 0.01; ***p < 0.001; and ****p < 0.0001.