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. 2022 Jan 19;9:789438. doi: 10.3389/fcell.2021.789438

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Copyright © 2022 Buscaglia, Northington, Aiken, Hoff and Bates.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Reduced Tuba1a does not interfere with netrin-1-induced axon growth rates. (A) Primary cortical neuron cell cultures were made from Tuba1a ^ND/+ mice and wildtype littermates. Cells were plated on glass-bottom dishes and images were collected every 10 min for an hour. Purified Netrin-1 was then added to the dish at 500 ng/ml and images were taken every 10 min for an additional hour. (n = 77 neurons; p = 0.0057, unpaired t-test) (B). Analysis was repeated for Tuba1a ^ND/+ mice (n = 91 neurons; p < 0.0001, and n = 83 neurons; p = 0.0488, unpaired t-test) (C). To determine if there was a difference in stimulated growth between the wildtype and Tuba1a ^ND/+ mice the growth values were compared at each time point. No differences were found at any time point.