FIGURE 1.

The summary and description of the study workflow in the potential mechanism of HLJDD in treating RA. The active ingredients and corresponding targets of HLJDD were obtained through TCMSP and BATMEN-TCM database. The RA-related targets were downloaded from four different databases, and the common targets were identified by intersecting ingredient targets and RA-related targets. GO and KEGG enrichment analysis was conducted, and PPI network with cytoHubba plug-in was used to select hub targets in the common targets. Finally, the complex botanical drugs-ingredients-hub-targets-disease network was constructed and validated by molecular docking and normalized expression of RA-related target genes from GEO datasets.