TABLE 1.

Cluster information of RA protein–protein interaction (PPI) network.

Cluster	Score	Nodes	Edges	Gene symbol
I	70.51	87	3032	CRP, CXCL12, SELL, FASLG, CCL2, MMP2, CXCL2, TIMP1, CXCR3, TNFSF13B, TNFRSF1A, CSF2, CX3CL1, CD44, CD19, JUN, VCAM1, CXCL8, CCL3, ITGAM, IL10RA, FOXP3, ALB, IL33, TNFSF11, VEGFA, CCL20, CXCR4, INS, CXCL1, FCGR2B, CXCL10, IL17A, ANXA5, CD86, FCGR2A, CCL5, CCR1, CSF1, SELE, STAT3, CXCL5, IL13, CD80, IL7, CCR5, CCR2, CSF1R, CCRL2, CD28, CXCR5, CD40, TLR9, TLR2, NLRP3, IL4, MAPK1, STAT1, IL2RA, CTLA4, TNF, IL6, NOS2, MAPK8, CD40LG, CASP1, KLRK1, IFNG, MMP9, CD69, IL2, TLR1, CSF3, PTGS2, TNFRSF1B, GZMB, GPR29, IL15, IL6R, CX3CR1, IL18, TLR4, IL10, IL1B, IL1A, ICAM1, IL1R1
II	11.00	11	55	CNR2, HRH4, OPRD1, S1PR1, CXCL6, BDKRB2, C5, BDKRB1, C5AR1, ANXA1, ADORA3
III	9.71	35	165	LTA, ITGAL, IRAK1, MAPK14, TGFB1, NFKB1, IL22, IL17RA, IL23A, NOD2, REL, HMGB1, SPP1, FAS, RELB, ITGB2, ITGA4, IL16, MMP1, MMP3, MIF, NFKBIA, SYK, IL23R, FOS, IL2RB, STAT4, IL21, ELANE, IL11, PDCD1, MPO, CD4, IL1RN, IFNB1
IV	8.86	15	62	HLA-DOA, PTPN22, HLA-DPB1, HLA-B, NLRP1, HLA-DMA, HLA-DRB5, MICA, HLA-DMB, HLA-DQB1, HLA-DQA2, CD247, CTSL, HLA-DQA1, P2RX7
V	7.00	7	21	MAEL, TDRD6, TDRD1, PIWIL1, DDX25, PIWIL2, TDRD7