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. 2022 Jan 25;15(1):dmm049105. doi: 10.1242/dmm.049105

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© 2022. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 2. — Over-representation of metabolic pathways and lipid classes upon bleomycin treatment and differential pathway responses in young and old mice. (A,B) Over-representation analysis of metabolic superpathways (A) and subpathways (B) in bleomycin-treated mice compared to controls. (C) GSEA of metabolic pathways in bleomycin-induced lungs compared to controls using KEGG annotations. (D,E) Over-representation analysis of lipid classes (D) and subclasses (E) in bleomycin-treated mice compared to controls. (F,H) Differential metabolic subpathway (F) and lipid subclass (H) responses among age groups according to fold change distributions in young and old mice. (G,I) Scatter plots showing log2 fold changes of detected metabolic subpathways (G) and lipid subclasses (I) in young and old mice, with their best linear fit (regression line, equation and coefficient of determination). The FDR values indicate differential pathway responses. The results for A-F and H are provided in Table S6. q<0.05 in A-E; FDR<0.05 in F-I. DAG, diacylglycerol; FDR, false discovery rate; GSEA, gene set enrichment analysis; n.s., not significant; PC, phosphatidylcholine; PE, phosphatidylethanolamine; PI, phosphatidylinositol; SAM, S-adenosylmethionine; TAG, triacylglycerol.