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. 2022 Jan 25;15(1):dmm049105. doi: 10.1242/dmm.049105

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© 2022. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 3. — Breakdown of macromolecules and degradation of collagen and extracellular matrix (ECM) reflect tissue turnover and repair in bleomycin-treated lungs. (A,B) Heat map (A) and box plots (B) showing log2 scaled abundance of indicated metabolites involved in protein degradation in bleomycin-treated and control lungs. (C,D) Heat map (C) and box plots (D) showing log2 scaled abundance of indicated metabolites involved in nucleic acid turnover in bleomycin-treated and control lungs. (E,F) Heat map (E) and box plots (F) showing log2 scaled abundance of indicated metabolites involved in collagen and ECM turnover in bleomycin-treated and control lungs. (G) Simplified scheme of arginine metabolism and urea cycle with connections to other metabolic pathways. In B, D and F, the lower and higher hinges represent the first and third quartiles, respectively; the median is indicated by the intermediate bar. The whiskers extend up to 1.5 times the interquartile range from each hinge; more distant data points are displayed as outliers. FDR<0.05. ADMA, asymmetric dimethylarginine; ADP, adenosine diphosphate; AICA, 5-aminoimidazole-4-carboxamide; Ala, alanine; AMP, adenosine monophosphate; Arg, arginine; Asp, aspartate; Bleo, bleomycin; CDP, cytidine diphosphate; CMP, cytidine monophosphate; FDR, false discovery rate; GABA, gamma-aminobutyrate; Glu, glutamate; GMP, guanosine monophosphate; n.s., not significant; Orn, ornithine; Pro, proline; SAM, S-adenosylmethionine; SDMA, symmetric dimethylarginine; TCA, tricarboxylic acid; UDP, uridine diphosphate; UMP, uridine monophosphate.