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. 2022 Jan 25;15(1):dmm049105. doi: 10.1242/dmm.049105

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© 2022. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 6. — Altered inflammation and immune modulation pathways in fibrotic lungs. (A,B) Heat map (A) and box plots (B) showing log2 scaled abundance of indicated eicosanoid lipids involved in inflammation and immune modulation in bleomycin-treated and control lungs. In B, the lower and higher hinges represent the first and third quartiles, respectively; the median is indicated by the intermediate bar. The whiskers extend up to 1.5 times the interquartile range from each hinge; more distant data points are displayed as outliers. FDR<0.05. (C) Simplified scheme of the eicosanoid pathway with the connections to other metabolomic pathways. (D) Box plots showing log2 values+1 of indicated cytokines/chemokines in the bronchioalveolar lavage (BAL) of young and old animals upon bleomycin treatment on day 21. Each dot represents an individual animal: Old Bleo, n=8; Old NaCl, n=6; Young Bleo, n=9; Young NaCl, n=5. Significance was assessed with a one-way ANOVA, stratified by age, and P-values were corrected using the FDR. Up- and downregulated metabolites in heat maps are annotated according to the changes in young mice (fold change and FDR<0.05). Bleo, bleomycin; FDR, false discovery rate; n.s., not significant; PC, phosphatidylcholine; PE, phosphatidylethanolamine; PI, phosphatidylinositol; PLA2, phospholipase A2; 12-HEPE, 12-hydroxyeicosapentaenoic acid; 12-HETE, 12-hydroxyeicosatetraenoic acid; 12-HHTrE, 12-hydroxyheptadecatrienoic acid; 14-HDoHE/17-HDoHE, 14-hydroxydocosahexaenoic acid/17-hydroxydocosahexaenoic acid; 15-HPETE, 15-hydroperoxyarachidonic acid.