FIGURE 4.

Diminution of striatal and nigral TH expression in Parkinsonian mice. (A) In the Str, all MPTP-lesioned mice tended to have around 25% less TH+ fiber density compared to controls. Control n = 5, MPTP + buffer n = 4, MPTP + cell n = 5. Kruskal-Wallis test followed by Dunn´s post-hoc test. (B) Nigral TH+ area decreased by 46% in buffer-treated mice (p < 0.05) and by 27% in hNSC-transplanted mice, compared to control animals. Control n = 5, MPTP + buffer n = 4, MPTP + cell n = 5. One-way ANOVA followed by Tukey´s post-hoc test. (A,B): * = p < 0.05, ** = p < 0.01. * = compared to same brain hemisphere of control. Data are expressed as mean ± standard error of the mean. Scale bars = 200 μm.