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. 2022 Feb 1;13:449. doi: 10.1038/s41467-021-27918-w

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a The WID-BC-index versus age in samples from the internal and external validation datasets. b Correlation with a polygenic risk score (PRS) based on 303 SNPs in the internal validation dataset. c ROC curve corresponding to the PRS evaluated in a subset of samples from the discovery set. d ROC curves of the WID-BC-index (black) or the WID-BC-index without 78 mQTLs previously associated with breast cancer (turquoise). Removal of mQTLs did not significantly influence performance of the WID-BC-index. e Correlation with body mass index (BMI) in controls. Assessment of the WID-BC-index with f family history, g age at menarche, h age at first live birth, i menopause, j hormone replacement therapy, k stage, l nodal status, m grade, n ER/PR status, and o HER2 status. e–j are based on controls from the internal and external validation datasets. ***p = 1.937e-05 in two-sided Welch’s t-test (Menopausal status), **p = 0.001 in two-sided Welch’s t-test (HRT). Box plots throughout (f–o) correspond to standard Tukey representation, with boxes indicating mean and interquartile range, and lines indicating smallest and largest values within 1.5 times of the 25^th and 75^th percentile, respectively. Dots indicate outlier values. No corrections for multiple adjustment were carried out. Source data are provided as a Source Data file.