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. 2022 Jan 19;12:770652. doi: 10.3389/fphar.2021.770652

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Copyright © 2022 Zhang, Niu, Ma, Chen, Wen, Li, Zhou, Deng, Shi, Pu, Yang, Wang, Zou, Chen and Ma.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Fenofibrate attenuates body mass, liver histology in HFD-fed mice. (A) Mice experiment process plan diagram. Effects of fenofibrate on bodyweight (B) and hip-width (C) after 14 weeks. These results are means ± SD (n=6−10 mice/group). *p < 0.05, **p < 0.01, ****p < 0.0001, HFD group versus control group, or fenofibrate + HFD-fed group versus HFD group. (D) Liver gross morphology, hepatic macrosteatosis, and fat deposition of mice in each group (original magnification ×200; scale bar, 50 μm). (E) Masson staining and F4/80 staining of liver tissue in each group (magnification ×200; scale bar, 50 μm).