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. 2022 Jan 19;12:770652. doi: 10.3389/fphar.2021.770652

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Copyright © 2022 Zhang, Niu, Ma, Chen, Wen, Li, Zhou, Deng, Shi, Pu, Yang, Wang, Zou, Chen and Ma.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Fenofibrate alleviates ER stress and elevates the expression of SERCA2b. The expression of Bip (A), CHOP (B), and SERCA2b (C) were measured by western blotting. Representative western blots are shown. These results are means ± SD (n = 5–9 mice/group). *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001, HFD group versus control group, or fenofibrate + HFD-fed group versus HFD group. (D) SERCA2b expression was determined by immunohistochemistry (scale bar, 20 μm); heart tissue was used as a positive and a negative control. (E) The percentage of stained area in immunohistochemistry. ****p < 0.0001, HFD group versus control group, or fenofibrate + HFD-fed group versus HFD group.