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. 2022 Jan 19;12:770652. doi: 10.3389/fphar.2021.770652

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Copyright © 2022 Zhang, Niu, Ma, Chen, Wen, Li, Zhou, Deng, Shi, Pu, Yang, Wang, Zou, Chen and Ma.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Let-7 regulates the expression of SERCA2b. (A) qPCR analysis confirmed that fenofibrate attenuates let-7 expression in HFD-fed mice after 14 weeks. These results are means ± SD (n=3−9 mice/group). **p < 0.01, ***p < 0.001, ****p < 0.0001, HFD group versus control group, or fenofibrate + HFD-fed group versus HFD group. (B) Sequences of the SERCA2b in different species. SERCA2b is highly conserved in different species. (C) Complementarity between the 3′ UTR of SERCA2b mRNA and let-7. The box indicates the seed region of the let-7 family. (D) Luciferase analysis of a reporter vector harboring the 3′ UTR of SERCA2b in HepG2 cells transfected with a negative control (NC) mimic or miR-let-7 mimic together with psiCHECK2-SERCA2b 3′ UTR reporter plasmids for 48 h. These results are means ± SD of three independent experiments. **p < 0.01, miR-let-7 mimic group versus negative control group.