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. 2022 Jan 19;12:818227. doi: 10.3389/fphar.2021.818227

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Copyright © 2022 He, Hu, Liu, Zhu, Zhang, You, Shao, Li, Zhang, Cui, He, Ge and Yang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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DEGs in patients with NASH and healthy people and the intersected genes of DEGs and predicted targets. The dataset (GSE135251) was downloaded from GEO Datasets. Then, DEGs were calculated by limma package and plotted by R. Volcano plot of DEGs (A) and heatmap plot of DEGs (B) were graphed and red dots represented up-regulated genes while blue represented down-regulated genes. Top ten up-regulated and down-regulated genes were labeled. Then, predicted targets of POL (D) were obtained from TCMSP database. The intersected genes (N&P) of DEGs and predicted targets (C) were graphed by Venn diagram. The network of corresponding compounds and core genes (N&P) (E) was graphed by Cytoscape. Blue circles represented constitutes of POL while red represented core genes (N&P).