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. 2022 Jan 19;12:818227. doi: 10.3389/fphar.2021.818227

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Copyright © 2022 He, Hu, Liu, Zhu, Zhang, You, Shao, Li, Zhang, Cui, He, Ge and Yang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Protein-protein network analysis and topological analysis of N&P. Protein-protein network of core genes (A) was graphed by Cytoscape. The network of corresponding components from POL and core genes (N&P) (B) was graphed by Cytoscape. Pink node represented the core genes while blue represented the corresponding components. Node size is proportional to its degree. The larger the area is, the more important it is in the network. Topological network of N&P (C) was graphed by GeneMANIA. The different color lines represented the network relationships while the different color circles represented the gene functions.