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. 2022 Jan 19;12:818227. doi: 10.3389/fphar.2021.818227

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Copyright © 2022 He, Hu, Liu, Zhu, Zhang, You, Shao, Li, Zhang, Cui, He, Ge and Yang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The effects of POL and Myr on the protein and mRNA expression of PTGS2 and the mRNA expression of CPT1a, FASN, SCD1, ACC1, and SREBP1c in FFA-induced L02. L02 cells were incubated with 300 μM FFA (oleic acid: palmitic acid = 2: 1) and treated with 6.25, 25, and 100 μg/ml POL and 20 μM Myr for 24 h, respectively. (A) Cell viabilities of L02 and RAW264.7 treated with 6.25, 25, and 100 μg/ml POL. The mRNA expression of PTGS2 (B), ACC1 (C), CPT1a (D), SREBP1c (E), SCD1 (F), and FASN (G) were determined by qt-PCR. Then, the protein expression of PTGS2 was detected by western blot (H) and immunoflurescence staining (I) and. The relative protein expression of PTGS2 was calculated (J). Comparing with model group, *p < 0.05, **p < 0.01, ***p < 0.001.