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. 2022 Jan 19;11:757791. doi: 10.3389/fonc.2021.757791

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Copyright © 2022 Chen, Zu, Zeng, Chen, Wei, Liu, Li, Zhou, Wang, Tan and Tan

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) The heatmap showed the 3-MRG expression in the prognostic signature based on different risk, clinicopathological characteristics, and survival status in the TCGA cohort. (B) GSEA revealed the top 5 up- and downregulated metabolism-related signaling pathways enriched in low- and high-risk groups. (C–E) The IC50 showed the chemosensitivity of cisplatin, gemcitabine, and paclitaxel in the low- and high-risk groups.