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Common Toxicity Criteria for Adverse Events (CTCAE) of the National Cancer Institute.
| Grade 1 | Grade 2 | Grade 3 | Grade 4 | |
|---|---|---|---|---|
| AST, IU/L | >1–3 | >3–5 | >5–20 | >20 |
| ALT, IU/L | >1–3 | >3–5 | >5–20 | >20 |
| ALP, IU/L | >1–2.5 | >2.5–5 | >5–20 | >20 |
| GGT, IU/L | >1–2.5 | >2.5–5 | >5–20 | >20 |
| Total bilirubin, mg/dL | >1–1.5 | >1.5–3 | >3–10 | >10 |
This assessment method is used to evaluate the severity of liver toxicity. The values are expressed as multiples of the ULN.
