TABLE 4.

DILI scale. Adapted from Fontana et al. (2009) and Aithal et al. (2011).

		Drug-induced liver injury network (DILIN) scale (Fontana et al., 2009)	DILI scale from the consensus of the international DILI expert working group (Aithal et al., 2011)
1	Mild	Elevation in ALT and/or ALP levels, but total serum bilirubin <2.5 mg/dl and INR<1.5	Elevated ALT/ALP concentration reaching criteria for DILI but bilirubin concentration <2× ULN
2	Moderate	Elevation in ALT and/or ALP levels, and serum bilirubin ≥2.5 mg/dl or INR ≥ 1.5	Elevated ALT/ALP concentration reaching criteria for DILI and bilirubin concentration ≥2× ULN, or symptomatic hepatitis
3	Moderate–severe	Elevation in ALT, ALP, bilirubin, and/or INR levels, and the patient is hospitalized or an ongoing hospitalization is prolonged because of DILI.
4	Severe	Elevation in ALT and/or ALP levels, total serum bilirubin is 2.5 mg/dl or greater, and there is at least one of the following:	Elevated ALT/ALP concentration reaching criteria for DILI, bilirubin concentration ≥2× ULN, and one of the following:
		1) Hepatic failure (INR ≥1.5, ascites, or encephalopathy);	INR ≥1.5
		2) Other organ failure believed to be due to DILI event	Ascites and/or encephalopathy, disease duration <26 weeks, and absence of underlying cirrhosis
			Other organ failure considered to be due to DILI
5	Fatal	Patient dies or undergoes liver transplantation because of DILI event	Death or transplantation due to DILI