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. 2021 Sep 16;36(2):266–272. doi: 10.1038/s41433-021-01725-5

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — IL-33 gene expression is decreased in RPE/choroid/sclera of AMD donors by more than 50% compared to normal age-matched donors (p = 0.03, two-tailed t-test) A but expression is unchanged in the retina B. RNA- sequencing data from Kim et al. (GSE99248). C ELISA analysis shows a reduction of IL-33 protein in RPE lysates from a mouse model of light-induced retinal damage (100k LUK/20 min), compared to naïve eyes (p = 0.08, Mann–Whitney U test). D Concurrently, RPE damage is apparent, indicated by an increase in the number of multinucleated cells (RPE cells containing ≥3 nuclei/cell within the cell boundary; *p = 0.02, Mann–Whitney U test), counted using ImageJ. E Representative images of RPE/choroid flatmounts, stained with phalloidin-Alexa555 and DAPI. Multinucleated cells are indicated (*). Scale bar is 80 μm.