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. 2022 Feb 2;7:33. doi: 10.1038/s41392-021-00855-2

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — PDGFRA is not necessary for PDGFA function in GBM cells. a Kaplan–Meier survival analysis of cases with PDGFA^High vs. PDGFA^Low from TCGA_GBM database. b PDGFA gene expression in TCGA PanCancer databases. c PDGFA-induced temporal expression of indicated proteins in LN18 cells pre-treated with vehicle or IMA. β-actin is used as loading control. d PDGFA-induced temporal expression of indicated proteins in LN18 cells transfected with control CRISPR/Cas9 or CRISPR/Cas9 targeting PDGFRA. e, f Enrichment of PDGF signaling-related genesets for TCGA_GBM cases with PDGFA^High/PDGFRA^High vs. PDGFA^Low or PDGFA^High/PDGFRA^Low vs. PDGFA^Low. g Categorization of PDGFA-associated proteins. h Significantly enriched KEGG pathways involving PDGFA through KEGG analysis on PDGFA interactome.