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. 2022 Feb 2;7:33. doi: 10.1038/s41392-021-00855-2

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Transcriptomic analyses on PDGFRA and EPHA2 co-upregulation in GBM cells. a Enrichment of signature genes of GBM molecular subtype for LN18 cells with co-transfection of EPHA2 and PDGFRA (RA^H/A2^H) vs. individual transfection (Non-RA^H/A2^H) (left two panels), as well as, cases with PDGFRA^High/EPHA2^High (RA^H/A2^H) vs. all other (Non-RA^H/A2^H) cases from TCGA_GBM mRNA expression dataset (right two panels). b Enrichment of signature genes of invasive growth for LN18 cells with RA^H/A2^H vs. Non-RA^H/A2^H cases (left two panels), as well as, cases with RA^H/A2^H vs. Non-RA^H/A2^H from TCGA_GBM mRNA expression dataset (right two panels). c Enrichment of signature genes of GBM G-CIMP subtype for LN18 cells with RA^H/A2^H vs. Non-RA^H/A2^H (left panel), as well as, cases with RA^H/A2^H vs. Non-RA^H/A2^H cases from TCGA_GBM mRNA expression dataset (right panel). d Heatmap graph of consistently altered genes in LN18 cells with RA^H/A2^H vs. Non-RA^H/A2^H (left lane) and cases with RA^H/A2^H vs. Non-RA^H/A2^H cases from TCGA_GBM mRNA expression dataset (right lane). e David analysis on consistently altered genes in LN18 cells with RA^H/A2^H vs. Non-RA^H/A2^H (left lane) and cases with RA^H/A2^H vs. Non-RA^H/A2^H cases from TCGA_GBM mRNA expression dataset (right lane). Categories with tops 3 protein counts are showed in the graph.