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. 2022 Feb 2;7:33. doi: 10.1038/s41392-021-00855-2

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Co-inhibition of PDGFRA and EPHA2 synergetically inhibits GBM cells. a IC₅₀ measurement of LN18 cells with forced expression of EPHA2 (left panel) or knockdown of EPHA2 (right panel) through MTT assay. b Antibody array analysis of LN18 cells treated with vehicle, EPHA2 inhibitor (ALW), and PDGFRA inhibitor (IMA). Significant changed proteins are labeled with frame and listed separately. c MTT assay-based drug combination evaluation in four GBM cell lines. d Representative images of orthotopic growth of U251 cells treated with vehicle, IMA, ALW, or IMA + ALW. e Statistic graph of tumor size using bioluminescence signal intensity. n = 8 for each group. f Representative immunohistochemistry images of Ki67 on tissue sections from mice with orthotopic GBM tumors treated by vehicle, IMA, ALW, or IMA + ALW. Scale Bar = 200 μm (upper) and 100 μm (lower).