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. 2022 Feb 2;7:33. doi: 10.1038/s41392-021-00855-2

Fig. 7.

Fig. 7

Analysis on transcriptomes of LN18PDGFRA−/− treated with PBS, PDGFA or EFNA1. a Volcano graph of genes affected by PDGFA or EFNA1 vs. PBS. b Venn diagram of genes affected by PDGFA or EFNA1 vs. PBS. c Venn diagram of genesets enriched by PDGFA or EFNA1-upreguleted genes. d GSEA graph of EMT hallmark signature enriched by PDGFA or EFNA1-regulated genes. e Schematic diagram of EPHA2 and PDGFRA-mediated PDGFA function in GBM cells. Both PDGFRA and EPHA2 mediate PDGFA function to promote invasive growth and therapeutic resistance of GBM cells (upper panel). Single pharmaceutical inhibition of EPHA2 or PDGFRA cannot effectively suppress PDGFA activity due to the existence of compensate pathway. Concurrent inhibition of PDGFRA and EPHA2, however, potently block PDGFA signaling transduction (lower panels).