Table 2.
Selection of methoctramine dose for antidotal therapy of mice poisoned by 2xLD50 of POX.
| Group | n/N* |
|---|---|
| POX 0.42 mg/kg, i.p. | 0/24 |
| POX + methoctramine 3 mg/kg, i.p. | 2/24 |
| POX + methoctramine 4 mg/kg, i.p. | 4/24 |
| POX + methoctramine 6 mg/kg, i.p. | 7/24 |
| POX + methoctramine 8 mg/kg, i.p. | 10/24 |
| POX + methoctramine 10 mg/kg, i.p. | 8/24 |
*n number of mice survival 120 h after POX poisoning.
N total number of mice in the group. POX—0.42 mg/kg, i.p.