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. 2022 Feb 1;12:1688. doi: 10.1038/s41598-022-05730-w

Table 2.

Selection of methoctramine dose for antidotal therapy of mice poisoned by 2xLD50 of POX.

Group n/N*
POX 0.42 mg/kg, i.p. 0/24
POX + methoctramine 3 mg/kg, i.p. 2/24
POX + methoctramine 4 mg/kg, i.p. 4/24
POX + methoctramine 6 mg/kg, i.p. 7/24
POX + methoctramine 8 mg/kg, i.p. 10/24
POX + methoctramine 10 mg/kg, i.p. 8/24

*n number of mice survival 120 h after POX poisoning.

N total number of mice in the group. POX—0.42 mg/kg, i.p.