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. 2022 Jan 28;5(5):e202101088. doi: 10.26508/lsa.202101088

Figure S8. Structural similarities among Treslin/TICRR, MTBP, and Ku70 proteins.

Figure S8.

(A) Contact maps of Ku70-like β-barrel domains of Treslin/TICRR (Alphafold 2 model), Ku70 (PDB: 5Y58_A), Sld7 (PDB: 3x37_B), and Sld3 (PDB: 3x37_A). Contact maps were generated using the Cocomaps server (cut-off distance value = 7 Å) (Vangone et al, 2011). β-strands are labeled 1–7 and coloured in red, orange, yellow, green, cyan, violet, and purple, respectively. β-strand contact pairs are labeled, showing the identical arrangement of the seven β-strands conserved among these Ku70-like β-barrel domains. In Sld3 the β-barrel is incomplete, missing β strands 1 and 2 (Ku70 barrel numbering). (B) Dali structural superposition of the vWA domains of human Treslin/TICRR (Treslin/TICRR Alphafold 2 model positions 1–250 in green), human MTBP (MTBP Alphafold 2 model positions 1–236 in cyan; Z-score 9.6 and RMSD 3.6 Å versus Treslin/TICRR), and yeast Ku70 (PDB: 5y58-A, positions 28–263 in purple; Z-score 10 and RMSD 3.8 Å versus Treslin/TICRR). (C) Dali structural superposition of the β-barrel domains of human Treslin/TICRR (Treslin/TICRR Alphafold 2 model position 299–424 in green), human MTBP (MTBP Alphafold 2 model positions 237–420 in cyan; Z-score 10.1 and RMSD 3.4 Å versus Treslin/TICRR), and yeast Ku70 (PDB: 5y58-A, positions 264–451 in purple; Z-score 13.3 and RMSD 2.6 Å versus Treslin/TICRR).