Table 2.
Sleep architecture and leg movement activity during sleep parameters in patients with idiopathic RLS and MS patients with RLS.
| Idiopathic RLS (n = 35) | MS with RLS (n = 17) | Student’s t-Test | Effect Size | ||||
|---|---|---|---|---|---|---|---|
| Mean | SD | Mean | SD | t-Value | P ≤ | Cohen’s d | |
| Sleep architecture | |||||||
| Time in bed, min | 526.9 | 91.24 | 446.4 | 48.92 | 3.398 | .0013* | 1.100 |
| Sleep period time, min | 497.9 | 90.04 | 413.0 | 55.63 | 3.562 | .00082* | 1.135 |
| Total sleep time, min | 415.1 | 97.17 | 362.8 | 56.93 | 2.049 | .046 | 0.657 |
| Sleep latency, min | 20.0 | 21.09 | 26.4 | 21.92 | −1.004 | NS | −0.295 |
| REM latency, min | 123.6 | 65.99 | 108.4 | 77.73 | 0.738 | NS | 0.212 |
| Stage shifts/h | 12.2 | 3.40 | 20.1 | 6.32 | −5.878 | .000001* | −1.556 |
| Awakenings/h | 4.7 | 2.63 | 5.8 | 2.18 | −1.531 | NS | −0.468 |
| Sleep efficiency, % | 78.1 | 12.44 | 81.2 | 8.63 | −0.909 | NS | −0.285 |
| Stage W, % | 17.2 | 13.16 | 12.0 | 8.82 | 1.471 | NS | 0.464 |
| Stage N1, % | 7.2 | 5.07 | 10.7 | 4.44 | −2.429 | .019 | −0.735 |
| Stage N2, % | 44.8 | 11.45 | 40.0 | 10.61 | 1.458 | NS | 0.437 |
| Stage N3, % | 15.5 | 8.15 | 20.1 | 9.85 | −1.784 | NS | −0.509 |
| Stage R, % | 15.3 | 5.67 | 17.2 | 6.55 | −1.084 | NS | −0.312 |
| Leg movement activity | |||||||
| PLMS index | 27.5 | 18.94 | 15.2 | 15.17 | 2.327 | .024 | 0.715 |
| SILMS index | 4.5 | 4.15 | 7.2 | 6.16 | −1.860 | NS | −0.511 |
| ISOLMS index | 11.0 | 5.42 | 12.7 | 4.12 | −1.175 | NS | −0.364 |
| Total LMS index | 43.0 | 22.43 | 35.1 | 19.44 | 1.230 | NS | 0.373 |
| Bilateral PLMS, % | 33.8 | 24.67 | 18.0 | 17.76 | 2.288 | .027 | 0.734 |
| Periodicity index | 0.601 | 0.189 | 0.362 | 0.228 | 3.999 | .00021* | 1.143 a |
| PLMS duration, s | 2.8 | 0.66 | 2.2 | 0.92 | 2.436 | .019 | 0.693 |
| SILMS duration, s | 2.5 | 0.79 | 2.0 | 0.51 | 2.431 | .019 | 0.770 |
| ISOS duration, s | 3.3 | 0.99 | 2.1 | 0.65 | 4.663 | .000023* | 1.474 a |
| PLMS index in REM sleep | 8.6 | 16.07 | 9.8 | 11.85 | −0.272 | NS | −0.085 |
| PLMS index in NREM sleep | 31.6 | 21.34 | 16.9 | 17.35 | 2.464 | .017 | 0.755 |
*
Significant after Bonferroni correction. aEffect size value > 0.8 (large effect). ISOLMS = isolated leg movements during sleep, LMS = leg movements during sleep, MS = multiple sclerosis, NS = not significant, PLMS = periodic leg movements during sleep, RLS = restless legs syndrome, SILMS = short-interval leg movements during sleep.