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. 2022 Jan 20;15:451–463. doi: 10.2147/JIR.S343263

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© 2022 Abdelgawad et al.

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Scheme 1 — The synthetic pathway of molecules IIIa–i. Reagents and conditions: a) NaOC2H5, C2H5OH, reflux, 6h, 99%; b) NaNO2, HCl, 0 oC, 2 h; c) Aromatic aldehyde, NaOH, stirring, 0 oC, 12 h; d) conc. HCl, methanol, rt, 7h, 66–93%.