Table 2.

In vitro COXs Inhibitory Action of Molecules IIIa–i

Compound No.	IC50 (µM)a		SIb
	COX-1	COX-2
IIIa	7.88 ± 0.14	4.78 ± 0.08	1.65
IIIb	6.86 ± 0.12	2.51 ± 0.09	2.73
IIIc	10.52 ± 0.24	3.87 ± 0.07	2.72
IIId	4.00 ± 0.09	0.67 ± 0.02	5.97
IIIe	7.52 ± 0.11	2.11 ± 0.07	3.56
IIIf	11.23 ± 0.27	0.95 ± 0.01	11.82
IIIg	9.20 ± 0.22	1.02 ± 0.03	9.02
IIIh	7.84 ± 0.16	2.43 ± 0.07	3.23
IIIi	3.25 ± 0.07	0.69 ± 0.02	4.71
Celecoxib	7.34 ± 0.18	1.11 ± 0.04	6.61

Notes: ^aIC₅₀: compound concentration required to produce 50% inhibition of COX-1 or COX-2 for means of three determinations, bold figures refer to submicromolar; ^bSI = IC₅₀ (COX-1)/ IC₅₀ (COX-2).