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Roles of m6A methylation on circRNAs
(A) circRNA production correlates with m6A levels and is modulated by ALKBH5 and METTL3. (B) m6A residues can drive efficient initiation of protein translation from circRNAs in a cap-independent manner. (C) m6A-containing circRNAs are endoribonucleolytically cleaved by YTHDF2-HRSP12-RNase P/MRP complex. (D) m6A suppression of circRNA immunity was mediated by YTHDF2, which can block endogenous circRNAs from activating the RIG-I antiviral pathway.
