Table 3.

Roles of circRNAs in the regulation of m⁶A modification

Role mode	circRNA	m6A regulators	m6A levels	Function	Diseases	References
Combined with m6A regulators	circSTAG1	ALKBH5	increase	promote the degradation of FAAH	depressive disorder	Huang et al.129
	circZbtb20	ALKBH5	decrease	improve Nr4a1 stability	ILC3 homeostasis	Liu et al.130
	circNOTCH1	METTL14	decrease	maintain NOTCH1 stability	NSCLC	Shen et al.131
	circPTPRA	IGF2BP1	block recognition of m6A	downregulate the stability of FSCN1 and MYC	bladder cancer	Xie et al.132
	circ0008399	WTAP	increase	upregulate TNFAIP3 expression	bladder cancer	Wei et al.133
Directly regulate m6A regulators	circRAB11FIP1	FTO	decrease	alter ATG5 and ATG7 expression	ovarian cancer	Zhang et al.134
Indirectly regulate m6A regulators	circ_0072083	ALKBH5	decrease	increase NANOG stability	glioma	Ding et al.135
	circMAP2K4	YTHDF1	affect recognition of m6A	–	HCC	Chi et al.136