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. 2022 Jan 10;27:880–893. doi: 10.1016/j.omtn.2022.01.005

Figure 2.

Figure 2

Histological analysis of representative genes in C2 and C3 clusters

(A) t-SNE clustering of human corneal endothelial cells colored by cell-cycle phases. (B) Proportion of cell-cycle stages per cluster. (C) Percentage of mitochondrial genes in each cell cluster. ∗∗∗∗p < 0.0001 (2-sided Wilcoxon rank-sum tests). (D) Density plot showing the cell distribution with different SASP scores across cell clusters. (E) Immunohistochemical staining of PCNA validated the presence of C2 cluster in endothelium sections of human cornea. The PCNA+ cells in limbus are indicated by black arrows. (F) Immunofluorescence analysis of IL-11 showing the C3 cells in human cornea endothelium tissues.