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. 2022 Jan 10;27:880–893. doi: 10.1016/j.omtn.2022.01.005

Figure 4.

Figure 4

Downregulation of lncRNA NEAT1 in FECD

(A) Gene expression enrichment scores for FECD-associated genes. (B) Signature score of FECD-associated genes across 4 clusters. (C) Heatmap of differentially expressed lncRNA in FECD RNA-seq. (D) lncRNA NEAT1 IGV tracks showing significantly downregulated expression of 2 isoforms between normal and FECD libraries. (E) Boxplot of normalized counts of lncRNA NEAT1 in RNA-seq. (F) qPCR verified the downregulation of lncRNA NEAT1 (n = 4). ns, not significant; ∗p < 0.05; ∗∗p < 0.01; ∗∗∗∗p < 0.0001 (2-tailed t test).