Table 2.
Clinical data of patients belonging to endotypes in combined (discovery and validation) analysis. The mean value ± standard error is presented for numerical variables with the total available observations/ patient numbers recorded in brackets. Categorical variables are presented as percent positive (% total positive/total available observations). P values are derived from Kruskal-Wallis and Chi squared tests testing for significant differences between endotypes for numerical and categorical values, respectively. Not included are readmission within 6 months, ER systolic, ER temperature, ICU admission, mortality, ER respiratory rate, ER urea, ER creatinine, and gender that were not significantly different (p > 0·05) between groups.
| Parameter | Mechanistic Endotypes |
|||||
|---|---|---|---|---|---|---|
| NPS (N = 83) | INF (N = 45) | IHD (N = 55) | IFN (N = 58) | ADA (N = 25) | P Val | |
| Age (years) | 59·4 ± 2·17 (83) | 58·3 ± 2·59 (45) | 62·7 ± 2·52 (55) | 51·2 ± 2·73 (58) | 37·2 ± 3·93 (25) | p < 0·0001 |
| Hospital Stay Days | 9·6 ± 0·9 (81) | 7·8 ± 1·6 (45) | 4·9 ±0·88 (54) | 7·6 ± 1·26 (58) | 5·3 ± 1·25 (22) | p < 0·0001 |
| ER Temperature (C) | 37·6 ± 0·16 (81) | 38·2 ± 0·18 (45) | 37·4 ± 0·13 (55) | 38·1 ± 0·14 (58) | 37·3 ± 0·22 | 0·00014 |
| ER Systolic (mm Hg) | 115·7 ± 2·47 (83) | 121·6 ± 3·44 (45) | 131·9 ± 3·21 (55) | 118·9 ± 2·87 (57) | 111·2 ± 3·44 (25) | 0·00030 |
| ER MAPa (mm Hg) | 90·5 ± 2·2 (83) | 94·3 ± 2·9 (45) | 105 ± 2·9 (55) | 92·7 ± 2·7 (57) | 89 ± 3·2 (25) | 0·00069 |
| ER Heart Rate (beats/ min) | 104·2 ± 2·5 (83) | 110·3 ± 2·7 (45) | 97·4 ± 2·7 (55) | 109 ± 2·5 (57) | 95·8 ±4·2 (25) | 0·00094 |
| At ER Altered Mental State | 22·9% (19/83) | 6·7% (3/45) | 3·6% (2/55) | 10·3% (6/58) | 4% (1/25) | 0·0030 |
| Treatment – Antibiotics | 88% (73/83) | 80% (36/45) | 72·7% (40/55) | 63·8% (37/58) | 44% (11/25) | 0·0050 |
| Blood Culture Result | 28·4% (23/81) | 28·9% (13/45) | 14·8% (8/54) | 8·9% (5/56) | 4·2% (1/24) | 0·0050 |
| At ER qSOFA | 1·2 ± 0·09 (83) | 0·9 ± 0·12 (45) | 0·7 ± 0·08 (55) | 0·9 ± 0·1 (58) | 1·2 ± 0·18 (25) | 0·0094 |
| ER Urea | 10·7 ± 0·85 (81) | 7·6 ± 0·79 (44) | 11 ± 103 (52) | 8·8 ± 0·92 (55) | 9·1 ± 0·94 (23) | 0·014 |
| Treatment - O2 Therapy | 41% (34/83) | 37·8% (17/45) | 29·1% (16/55) | 26·3% (15/57) | 8% (2/25) | 0·019 |
| ER 24H SOFA Score | 2·5 ± 0·24 (83) | 2·2 ± 0·32 (45) | 1·4 ± 0·21 (55) | 1·8 ± 0·24 (58) | 1·7 ± 0·34 (25) | 0·023 |
| ER Creatinine | 106 ± 519 (83) | 89·2 ± 7·9 (44) | 113 ± 897 (55) | 108 ± 132 (56) | 80·5 ± 4·37 (24) | 0·026 |
| ER Diastolic (mm Hg) | 70·3 ± 1·6 (81) | 68·5 ± 2·3 (45) | 75·6 ± 1·9 (55) | 73·5 ± 1·8 (57) | 67·6 ± 1·8 (25) | 0·046 |
| Within 72 h SOFA | 1·5 ± 0·24 (83) | 1·8 ± 0·41 (45) | 0·5 ± 0·15 (55) | 1·6 ± 0·36 (58) | 1 ± 0·31 (25) | 0·060 |
MAP = Mean arterial pressure