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. 2022 Jan 18;12:511078. doi: 10.3389/fphar.2021.511078

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Copyright © 2022 Hall, Rapinski, Spoor, Eid, Saleem, Arnason, Foster, Cuerrier, Haddad and Harris.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Principal component analysis of Cree medicinal plant biological activity subgroups. Groupings reflect rankings based on Syndromic Importance Values assigned to each plant through interviews with Cree elders; groups quartiles refer to the degree of relationship of plant use with diabetes symptoms. (A) Analysis using all evaluated bioassays. (B) Analysis using primary anti-diabetic bioassays. (C) Analysis using secondary anti-diabetic bioassays. (D) Analysis using herb-drug interaction bioassays. Central circles represent 95% confidence interval on full data sets. Ellipses indicate 95% confidence intervals on groupings.