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. 2022 Jan 18;12:511078. doi: 10.3389/fphar.2021.511078

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Copyright © 2022 Hall, Rapinski, Spoor, Eid, Saleem, Arnason, Foster, Cuerrier, Haddad and Harris.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Pearson correlation plots of the SIV and PIV of Cree medicinal plants bioactivity in (A) All assays, r ² = 0.3158, p = 0.019, (B) Primary anti-diabetes Assays, r ² = 0.0103, p = 0.7, (C) Secondary anti-diabetes Assays, r ² = 0.1952, p = 0.076, and (D) Safety assays, r ² = 0.3892, p = 0.0074. Greater SIV values indicate greater associated anti-diabetic potential based on ethnobotanical evidence. Greater PIV values indicate more significant relative activity in associated bioassays.