Table 3.
Comparison of biochemical parameters
| Biochemical parameters | Periodontally healthy | Gingivitis | Periodontitis | |||
|---|---|---|---|---|---|---|
| Mean | SD | Mean | SD | Mean | SD | |
| IL-1β | 21.73 | 17.53 | 44.63 | 40.63 | 61.15* | 55.24 |
| IL-1ra | 6.12 | 3.54 | 5.71 | 2.10 | 4.91 | 2.02 |
| IL-2 | 11.13 | 10.69 | 14.92 | 28.19 | 8.73 | 7.19 |
| IL-4 | 3.53 | 1.68 | 3.64 | 1.17 | 4.38 | 2.25 |
| IL-5 | 1.44 | 0.71 | 1.49 | 0.68 | 3.62 | 8.76 |
| IL-6 | 7.03 | 3.90 | 12.60 | 13.51 | 17.59* | 37.66 |
| IL-7 | 4.16 | 3.92 | 3.63 | 1.40 | 4.92 | 4.61 |
| IL-8 | 137.33 | 125.88 | 94.64 | 126.95 | 93.13 | 89.84 |
| IL-9 | 2.22 | 0.87 | 2.07 | 1.00 | 2.41 | 1.10 |
| IL-10 | 75.35 | 55.99 | 79.97 | 34.37 | 69.79 | 35.98 |
| IL-12 | 51.43 | 65.18 | 48.24 | 26.70 | 50.69 | 28.77 |
| IL-13 | 37.37 | 23.86 | 28.71 | 18.16 | 20.93 | 14.14 |
| IL-15 | 12.36 | 6.44 | 10.51 | 7.26 | 6.96* | 4.52 |
| IL-17 | 2.89 | 1.39 | 3.05 | 2.08 | 3.23 | 1.82 |
| Eotaxin | 12.55 | 31.28 | 7.11 | 2.04 | 6.73 | 2.69 |
| FGF-β | 6.66 | 2.43 | 16.86 | 33.74 | 7.87 | 5.04 |
| G-CSF | 5.61 | 7.07 | 4.63 | 4.60 | 5.23 | 4.10 |
| GM-CSF | 14.92 | 7.40 | 13.92 | 6.33 | 11.75 | 7.64 |
| IP-10 | 2.66 | 5.27 | 3.24 | 5.79 | 9.85* | 33.11 |
| MIP-1α | 6.74 | 4.77 | 10.45 | 8.32 | 16.14* | 35.36 |
| MIP-1β | 152.98 | 117.10 | 357.26 | 639.24 | 126.93 | 135.86 |
| PDGF | 6.10 | 4.01 | 5.27 | 2.89 | 5.68 | 1.85 |
| RANTES | 171.79 | 669.83 | 47.69 | 40.40 | 69.97 | 83.36 |
| TNF-α | 1.50 | 0.73 | 1.74 | 0.50 | 1.98 | 1.08 |
| VEGF | 70.25 | 52.25 | 61.42 | 51.60 | 109.86* | 92.94 |
| IFN-γ | 3.59 | 2.06 | 3.76 | 1.55 | 3.91 | 1.84 |
| MCP-1 | 5.62 | 3.91 | 8.14 | 7.56 | 10.64* | 4.39 |
*
Significant difference from periodontally healthy (p < 0.05).