Table 3. Model-Based Hazard Ratios for DCM and Partial DCM Phenotypes in First-degree Relatives of Patients With DCM.
| Predictor | DCMa | DCM or partial phenotypesa | ||
|---|---|---|---|---|
| HR (95% CI) | P value | HR (95% CI) | P value | |
| Proband race and ethnicity | ||||
| Non-Hispanic | ||||
| White | 1 [Reference] | 1 [Reference] | ||
| Black | 1.89 (1.26-2.83) | .002 | 1.27 (0.99-1.63) | .06 |
| Hispanic | ||||
| White | 1.28 (0.64-2.54) | .48 | 1.04 (0.66-1.65) | .87 |
| Black | 1.51 (0.29-7.82) | .63 | 0.93 (0.24-3.61) | .92 |
| Proband age at diagnosis, quartile | ||||
| I (4.73-34.33 y) | 2.19 (1.19-4.00) | .01 | 1.67 (1.14-2.44) | .008 |
| II (34.34-44.16 y) | 1.64 (0.91-2.95) | .10 | 1.60 (1.09-2.35) | .02 |
| III (44.18-53.62 y) | 1.23 (0.65-2.31) | .53 | 1.28 (0.91-1.79) | .15 |
| IV (53.66-82.67 y) | 1 [Reference] | 1 [Reference] | ||
Abbreviations: DCM, dilated cardiomyopathy; GEE, generalized estimating equation; GLMM, generalized linear mixed model; HR, hazard ratio.
a
Within-program HRs and Wald 95% CIs for a Weibull proportional hazards survival model were obtained from a GEE-type GLMM fit to current disease status data (eTables 5 and 6 in Supplement 1; Supplement 3) and are adjusted for proband and first-degree relative sex and site in addition to other variables shown here; 1692 first-degree relatives contributed to this analysis (1 non-Hispanic White first-degree relative was excluded due to missing covariate data). Two-sided P values are for the null hypothesis that the HR is 1.