Figure 1. Enrollment, Randomization, and Follow-up of Patients in the HYPO-ECMO Trial.

ECMO indicates extracorporeal membrane oxygenation; HYPO-ECMO, Hypothermia During ECMO.

^aA patient may have been excluded based on 1 or more of the listed reasons.

^bDefined as a state of imminent death without any medical therapeutic option.

^cThe proper equipment was not available, a certified investigator was not on-site, or there was not enough time (>6 hours after ECMO).

^dVoluntary or accidental with cardiotoxic drugs (eg, β-blockers, calcium channel blockers).