Table 3. Odds of Reduced Cognitive Function and PARsa.
| Variable | Odds of reduced cognitive function assessing percentage of BF quartiles (n = 8935) | Odds of reduced cognitive function assessing VAT quartiles (n = 6586) | ||||
|---|---|---|---|---|---|---|
| Odds ratio (95% CI) | P value | Partial PAR (95% CI) | Odds ratio (95% CI) | P value | Partial PAR (95% CI) | |
| Age (per 10 y) | 2.72 (2.50-2.96) | <.001 | NA | 2.66 (2.39-2.96) | <.001 | NA |
| Women | 0.36 (0.30-0.43) | <.001 | NA | 0.32 (0.26-0.41) | <.001 | NA |
| Height, cm | 0.99 (0.98-1.00) | .005 | NA | 0.98 (0.97-1.00) | .009 | NA |
| No postsecondary education | 1.98 (1.71-2.28) | <.001 | 20.1 (14.5-25.5) | 2.01 (1.65-2.44) | <.001 | 13.6 (8.4-18.8) |
| IHRS | ||||||
| High vs low risk | 1.37 (1.15-1.62) | <.001 | 19.2 (8.3-29.6) | 1.26 (1.01-1.56) | .04 | 14.5 (2.5-26.0) |
| Moderate vs low risk | 1.16 (1.00-1.35) | .05 | 1.18 (0.99-1.41) | .07 | ||
| Vascular brain injury | 1.34 (1.12-1.60) | .001 | 6.9 (2.6-11.1) | 1.35 (1.08-1.69) | .009 | 5.7 (0.9-10.5) |
| Percentage of BF | VAT quartiles | |||||
| Quartile 2 vs 1 | 1.31 (1.09-1.58) | .005 | 20.5 (7.0-33.2) | 1.05 (0.83-1.34) | .68 | 19.6 (2.0-36.0) |
| Quartile 3 vs 1 | 1.21 (1.00-1.46) | .05 | 1.27 (1.00-1.61) | .05 | ||
| Quartile 4 vs 1 | 1.43 (1.18-1.73) | <.001 | 1.42 (1.11-1.81) | .006 | ||
Abbreviations: BF, body fat; IHRS, INTERHEART Risk Score; NA, not applicable; PAR, population attributable risk; VAT, visceral adipose tissue.
a
Logistic regression further adjusted for ethnicity and recruiting center. Reduced cognitive function was defined as those with a Digital Symbol Substitution Test score less than 1 SD (15.7) below the mean (74.0) based on the Canadian Alliance for Healthy Hearts and Minds participants.