Table 3.
Nominally Significant Local Genetic Covariance (ρg) at 69 Candidate Loci From Previous GWAS
| Locus known phenotype(s) | Pheno 1 | Pheno 2 | Candidate region | Local ρg, p valuea | Candidate gene(s) | |||
| Chr | Start | End | N SNVs | |||||
| Any migraine | Any migraine | SVS | 1 | 3065568 | 3116361 | 97 | −1.1E-04, 0.04584 | PRDM16 |
| Any migraine/CeAD | Any migraine | CeAD | 6 | 12758654 | 13119871 | 486 | 2.3E-03, 0.00021 | PHACTR1/EDN1 |
| Any migraine | MO | CeAD | 2.2E-03, 0.01023 | |||||
| Any migraine | Any migraine | CeAD | 6 | 96682566 | 97082880 | 562 | 2.1E-03, 0.00080 | FHL5 |
| Any migraine | MO | CeAD | 2.5E-03, 0.00337 | |||||
| Any migraine | Any migraine | CeAD | 10 | 95952031 | 97039458 | 1737 | 1.6E-03, 0.04244 | PLCE1 |
| Any migraine | Any migraine | AS | 10 | 123910423 | 124326089 | 891 | −1.3E-04, 0.02415 | ARMS2/HTRA1 |
| Any migraine | Any migraine | IS | −1.2E-04, 0.03811 | |||||
| Any migraine | Any migraine | CeAD | 12 | 4446116 | 4570190 | 232 | −1.0E-04, 0.03432 | FGF6 |
| Any migraine | Any migraine | CeAD | 12 | 57256380 | 57545756 | 360 | 3.1E-03, 0.00003 | LRP1 |
| Any migraine | MO | CeAD | 2.3E-03, 0.00932 | |||||
| Any migraine | Any migraine | LAS | −1.6E-04, 0.02121 | |||||
| Stroke | Any migraine | AS | 13 | 47062093 | 47323718 | 502 | −8.3E-05, 0.03039 | LRCH1 |
| Stroke | Any migraine | IS | −8.1E-05, 0.03382 | |||||
| Any migraine | Any migraine | IS | 17 | 78235300 | 78384523 | 255 | −7.9E-05, 0.04741 | RNF213 |
Abbreviations: AS = all stroke; bp = base pair; CeAD = cervical artery dissection; GWAS = genome-wide association study; IS = ischemic stroke; LAS = large artery stroke; MO = migraine without aura; SNV = single nucleotide variation; SVS = small vessel stroke.
a
Multiple testing significance threshold is p < 0.0007 (=0.05/69).