Table 4.
Pairwise MTAG Genome-wide Significant Associations That Are Also Nominally Significant in Original GWAS
| Pheno 1 | Pheno 2 | SNV rsID | Chr | bp | Segment (bp)a | Coded/ref allele | GWAS association (Z score, p value) | MTAG association (beta [SE], pMTAG) | Novel locus for pheno no. | Candidate gene | ||
| Pheno 1 | Pheno 2 | Pheno 1 | Pheno 2 | |||||||||
| Any migraine | CeAD | rs6693567 | 1 | 150510660 | 150065704–150714741 | C/T | 5.7, 1.2E-08 | 3.2, 1.4E-03 | 0.016 (0.003), 3.1E-09 | 0.163 (0.028), 3.4E-09 | 2 | ADAMTSL4/ECM1 |
| Any migraine | SVS | rs191602009 | 2 | 203795717 | 203439395–204264839 | G/A | −5.7, 1.1E-08 | −4.9, 8.2E-07 | −0.022 (0.004), 6.9E-09 | −0.025 (0.004), 8.1E-09 | 2 | ALS2CR8 (CARF) |
| Any migraine | CeAD | rs9349379 | 6 | 12903957 | 12568218–13148388 | G/A | −9.6, 5.8E-22 | −6.1, 1.2E-09 | −0.024 (0.002), 6.2E-24 | −0.251 (0.024), 1.8E-25 | PHACTR1/EDN1 | |
| MO | CeAD | rs9349379 | 6 | 12903957 | 12681855–13145093 | G/A | −6.0, 2.1E-09 | −6.1, 1.2E-09 | −0.026 (0.004), 1.2E-12 | −0.257 (0.031), 8.0E-17 | ||
| Any migraine | CeAD | rs2971603 | 6 | 97035418 | 96319657–97267047 | T/C | 10.8, 2.8E-27 | 3.4, 6.4E-04 | 0.031 (0.003), 5.8E-28 | 0.267 (0.028), 8.8E-22 | 2 | FHL5 |
| Any migraine | CeAD | rs9486725 | 6 | 97061159 | 96319657–97267047 | T/C | 10.6, 3.5E-26 | 4.3, 1.4E-05 | 0.027 (0.002), 2.4E-27 | 0.251 (0.025), 1.4E-23 | 2 | |
| MO | CeAD | rs9486725 | 6 | 97061159 | 96643134–97267047 | T/C | 7.1, 1.3E-12 | 4.3, 1.4E-05 | 0.030 (0.004), 4.5E-15 | 0.245 (0.032), 2.7E-14 | 1, 2 | |
| Any migraine | CeAD | rs57866767 | 10 | 96023077 | 95798179–96274157 | C/T | −7.6, 2.3E-14 | −2.1, 3.6E-02 | −0.018 (0.002), 1.3E-14 | −0.157 (0.024), 4.9E-11 | 2 | PLCE1 |
| Any migraine | CeAD | rs11187838 | 10 | 96038686 | 95798179–96274157 | A/G | −7.6, 3.0E-14 | −2.4, 1.8E-02 | −0.018 (0.002), 1.4E-14 | −0.161 (0.024), 1.8E-11 | 2 | |
| Any migraine | CeAD | rs7940646 | 11 | 10669228 | 10454911–10899696 | T/C | −7.5, 5.0E-14 | −2.6, 1.0E-02 | −0.019 (0.002), 1.9E-14 | −0.174 (0.026), 1.1E-11 | 2 | MRVI1 |
| Any migraine | CeAD | rs11172113 | 12 | 57527283 | 57057912–57745756 | C/T | −14.7, 5.6E-49 | −5.4, 5.1E-08 | −0.035 (0.002), 8.5E-51 | −0.328 (0.024), 9.2E-42 | 2 | LRP1 |
| Any migraine | LAS | rs11172113 | 12 | 57527283 | 57056380–57745756 | C/T | −14.0, 1.9E-44 | 2.9, 3.8E-03 | −0.034 (0.002), 3.6E-44 | 0.023 (0.003), 4.4E-13 | 2 | |
| MO | CeAD | rs11172113 | 12 | 57527283 | 57302981–57734912 | C/T | −8.1, 4.3E-16 | −5.4, 5.1E-08 | −0.033 (0.004), 1.2E-19 | −0.282 (0.031), 1.0E-19 | 1, 2 | |
Abbreviations: bp = base pair; CeAD = cervical artery dissection; GWAS = genome-wide association study; LAS = large artery stroke; MO = migraine without aura; MTAG = multi-trait analysis of GWAS; SNV = single nucleotide variation; SVS = small vessel stroke.
a
Span of genome-wide significant MTAG associations for either phenotype and maximum distance 200 kb.