Figure 3:

Diagram of apoptotic pathways activated by gyrophoric acid. The protein network shows anti-apoptotic and pro-apoptotic proteins known to be involved in induction of apoptosis, including proteins that respond to intracellular DNA damage and repair or extracellular apoptotic signals such as death domain receptors. The protein network was generated using proteins known to be involved in apoptosis based on gene ontology terms. String v11.0 was used to render a protein network using the highest stringency settings with removal of unconnected proteins.