Table 1.

PK parameters of HZ-0408b after single administration.

Dosage	Sex	AUC(0-t)	AUC(0-∞)	t1/2	Tmax	CL	Vz	Cmax
mg/kg		mg/L*h	mg/L*h	d	h	L/h/kg	L/kg	mg/L
1	F	863.58	1020.793	2.7	72	0.001	0.092	6.52
	M	3754.525	3874.355	7.8	8	0	0.07	14.86
5	F	7214.735	7807.16	14.2	72	0.001	0.315	20.22
	M	8422.54	9040.203	12.8	72	0.001	0.245	27.54

AUC(0-∞) = area under the plasma concentration-time curve extrapolated to infinity; AUC(0-t) = area under the plasma concentration-time curve from time zero to the time of the last quantifiable concentration; t1/2 = plasma elimination half-life; Tmax = time when Cmax was reached; Cmax = maximum observed serum concentration; Vz = apparent volume of distribution during terminal elimination phase; CL = serum clearance.