FIGURE 6.

Potential inhibitors of ceramides synthesis pathways. Ceramides can be synthesized through three different pathways. First, de novo synthesis pathway which can be repressed by inhibiting ceramide synthases or SPT. Second sphingomyelin hydrolysis pathway that can be inhibited via functional inhibitor of acid or neutral sphingomyelinase or Ceramides can be synthesized through three different pathways. First, De novo synthesis pathway which can be repressed by inhibiting ceramide synthases or Serine palmitoyl-transferase. Second, sphingomyelin hydrolysis pathway that can be inhibited via functional inhibitor of acid or neutral sphingomyelinase. Lastly, inhibition of salvage pathway through depletion of ceramide precursors (ceramide synthases inhibition), or via increasing ceramide metabolism by ceramidases. [CerS, ceramide synthases; SPT, serine palmitoyl-transferase].