Table 2.

Clinical characteristics at the time of AKI/acute interstitial nephritis

Patient	Drug	Baseline Creatinine (mg/dl)	Drug Duration before AKI (mo)	Creatinine at AKI (mg/dl)	Peak Creatinine at AKI (mg/dl)	Urine WBC/hpf at AKI	Proteinuria/Osmolality Ratio (mg/mOsm)	Kidney Biopsy	Initiation of Dialysis
No. 1	Nivolumab	1	4	4.2	5.6	1–3	0.64	Yes, AIN	No
No. 2	Nivolumab	1.1	4	2.3	2.3	21–30	1.8	No	No
No. 3	Nivolumab	0.8	12	3.27	3.4	No	0.76	Yes, AIN	No
No. 4	Nivolumab and ipilimumab	0.9	1	6.5	6.5	No	0.54	No	No
No. 5	Nivolumab and ipilimumab	0.9	1	5.3	6.8	1–3	4.78	No	Yes
No. 6	Nivolumab and ipilimumab	1	3	5.2	5.9	31–40	1.16	No	No
No. 7	Nivolumab and ipilimumab	0.6	3	1.7	1.7	1–3	0.56	No	No
No. 8	Pembrolizumab	0.8	46	2.4	2.5	11–20	0.57	Yes, AIN	No
No. 9	Pembrolizumab	1.3	1	2.7	3.1	21–30	0.75	Yes, AIN	No
No. 10	Pembrolizumab	0.9	3	1.89	1.89	4–10	0.37	No	No
No. 11	Pembrolizumab	0.8	6	1.6	1.7	No	0.86	No	No
No. 12	Pembrolizumab	3	13	6	7.31	11–20	12.3	No	No
No. 13	Pembrolizumab	0.8	4	1.4	1.5	1–3	0.16	Yes, AIN	No
No. 14	Pembrolizumab	1.7	1	2.8	6.8	NA	0.64	No	Yes

WBC, white blood cell; hpf, high power field; AIN, acute interstitial nephritis; NA, not available.