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Differential cytokine regulation in perivascular niches.
CXCL12 secreted from peri-arteriolar NG2-expressing Nes-GFP+ stromal cells regulate HSC maintenance. CXCL12 derived from broadly distributed LepR+ peri-sinusoidal stromal cells controls mobilization of HSCs. Uniformly distributed LepR-expressing cells are the main source of SCF essential for HSC maintenance.
